Iapp^{tm2(IAPP*S53G)Nole}
Targeted Allele Detail

Summary

• Symbol: Iapp^{tm2(IAPP*S53G)Nole}
• Name: islet amyloid polypeptide; targeted mutation 2, Norman L Eberhardt
• MGI ID: MGI:7620150
• Synonyms: hIAPP^S20G
• Gene: Iapp Location: Chr6:142244151-142249546 bp, + strand Genetic Position: Chr6, 73.81 cM
• Alliance: Iapp^{tm2(IAPP*S53G)Nole} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241122
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 102 bp part of exon 3 was replaced with the equivalent sequence from a mutated human IAPP cDNA with an A>G (UniProt:P10997:p.S53G) mutation and a loxP site flanked neomycin resistance gene cassette was inserted downstream of the gene. This mutation is associated with premature onset type 2 diabetes in the Asian population. (J:241122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iapp Mutation: 14 strains or lines available

References

• Original: J:241122 Hiddinga HJ, et al., Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance. J Diabetes Investig. 2012 Mar 28;3(2):138-47
• All: 2 reference(s)