Atrx^tm1.2Rjg
Targeted Allele Detail

Summary

• Symbol: Atrx^tm1.2Rjg
• Name: ATRX, chromatin remodeler; targeted mutation 1.2, Richard Gibbons
• MGI ID: MGI:7619780
• Synonyms: Atrx^delta18
• Gene: Atrx Location: ChrX:104841221-104972978 bp, - strand Genetic Position: ChrX, 47.26 cM
• Alliance: Atrx^tm1.2Rjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115836
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo was inserted into intron 17 and a loxP sites into intron 18. Excision of this exon would still allow production of the shorter isoform containing exons 1-11. Cre-mediated recombination removed exon 18. (J:115836)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atrx Mutation: 79 strains or lines available

References

• Original: J:115836 Garrick D, et al., Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet. 2006 Apr;2(4):e58
• All: 1 reference(s)