Asic1^tm1.2Ccli
Targeted Allele Detail

Summary

• Symbol: Asic1^tm1.2Ccli
• Name: acid-sensing ion channel 1; targeted mutation 1.2, Cheng-Chang Lien
• MGI ID: MGI:7618262
• Synonyms: Asic1 KO
• Gene: Asic1 Location: Chr15:99568249-99599011 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Asic1^tm1.2Ccli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette, and cre-mediated recombination removed the loxP flanked sequences including exon 2. (J:253311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic1 Mutation: 43 strains or lines available

References

• Original: J:253311 Lin SH, et al., Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci. 2015 Jun;41(12):1553-68
• All: 2 reference(s)