Sema5a^em1Rojg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sema5a^em1Rojg
• Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; endonuclease-mediated mutation 1, Roman J Giger
• MGI ID: MGI:7618232
• Synonyms: Sema5a^GAG, Sema5a (R747E_R749E)
• Gene: Sema5a Location: Chr15:32244959-32696487 bp, + strand Genetic Position: Chr15, 13.02 cM
• Alliance: Sema5a^em1Rojg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9mediated gene editing, nucleotide substitution leading to amino acids R747E and R749E point mutations were introduced to glycosaminoglycan (GAG) binding sites. (J:346588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema5a Mutation: 67 strains or lines available

References

• Original: J:346588 Nagy GN, et al., Structure and function of Semaphorin-5A glycosaminoglycan interactions. Nat Commun. 2024 Mar 28;15(1):2723
• All: 1 reference(s)