Gt(ROSA)26Sor^{tm1(CAG-Naaa)Dpio}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Naaa)Dpio}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Daniele Piomelli
• MGI ID: MGI:7618222
• Synonyms: Gt(ROSA)26Sor^{tm1(Naaa)Dpio}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Naaa)Dpio} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339268
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Naaa)Dpio} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Naaa (MGI:1914361)

• Mutation details: A loxP flanked transcriptional stop cassette, a synthetic CAGG promoter and a mouse Naaa gene were incorporated into the Gt(ROSA)26Sor locus. The presence of the loxP flanked transcriptional stop cassette allows the expression of the Naaa gene to be dependent upon Cre recombinase. (J:339268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:339268 Pontis S, et al., N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis. Pharmacol Res. 2020 Oct;160:105064
• All: 3 reference(s)