Hba-a1^em1Beis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hba-a1^em1Beis
• Name: hemoglobin alpha, adult chain 1; endonuclease-mediated mutation 1, Brant Isakson
• MGI ID: MGI:7616788
• Synonyms: Hba1^delta36-39
• Gene: Hba-a1 Location: Chr11:32233672-32234486 bp, + strand Genetic Position: Chr11, 18.86 cM
• Alliance: Hba-a1^em1Beis page

Mutation origin

• Strain of Origin: C57BL/6 x SJL

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 gene editing technology was used to generate an in-frame deletion of 12 nucleotides that removed amino acid residues 36-39 (NH2-SFPT-COOH). (J:346559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba-a1 Mutation: 3 strains or lines available

References

• Original: J:346559 Keller TCS 4th, et al., Endothelial alpha globin is a nitrite reductase. Nat Commun. 2022 Oct 27;13(1):6405
• All: 1 reference(s)