Mapk12^tm2.1Cnd
Targeted Allele Detail

Summary

• Symbol: Mapk12^tm2.1Cnd
• Name: mitogen-activated protein kinase 12; targeted mutation 2.1, Ana Cuenda
• MGI ID: MGI:7615245
• Synonyms: Mapk12^D171A, p38gamma^171A
• Gene: Mapk12 Location: Chr15:89014787-89024906 bp, - strand Genetic Position: Chr15, 44.65 cM
• Alliance: Mapk12^tm2.1Cnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340398
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Aspartic acid codon 171 (GAC) in exon 7 was changed to alanine (GCC) (p.D171A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 7. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation renders the encoded peptide catalytically inactive. (J:340398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk12 Mutation: 19 strains or lines available

References

• Original: J:340398 Sabio G, et al., p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. J Cell Sci. 2010 Aug 1;123(Pt 15):2596-604
• All: 2 reference(s)