Ptgs2^tm1Bloa
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Bloa
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Anders Blomqvist
• MGI ID: MGI:7615053
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Bloa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346185
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A LoxP-neo cassette with a 3' polyA-LoxP was inserted upstream of the start codon and a Td-Tomato-2A cassette was inserted downstream of the start codon via homologous recombination. Cre-mediated recombination to remove the neo cassette will allow expression of the reporter and endogenous gene. (J:346185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 68 strains or lines available

References

• Original: J:346185 Shionoya K, et al., Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2122562119
• All: 1 reference(s)