Onecut1^tm1.2Mga
Targeted Allele Detail

Summary

• Symbol: Onecut1^tm1.2Mga
• Name: one cut domain, family member 1; targeted mutation 1.2, Maureen A Gannon
• MGI ID: MGI:7614989
• Gene: Onecut1 Location: Chr9:74769203-74796930 bp, + strand Genetic Position: Chr9, 41.93 cM
• Alliance: Onecut1^tm1.2Mga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216471
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding region and an FRT site flanked neo cassette with a 3' loxP site was inserted downstream of the coding region. Germ-line flp-mediated recombination removed the neo cassette, leaving the coding region floxed. Cre-mediated recombination removed the floxed segment. (J:216471)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Onecut1 Mutation: 10 strains or lines available

References

• Original: J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
• All: 1 reference(s)