Setd2^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Setd2^tm1.1Bcgen
• Name: SET domain containing 2; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7614315
• Synonyms: Setd2^fl
• Gene: Setd2 Location: Chr9:110361368-110447703 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252536
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 3. Flp-mediated recombination removed the selection cassette inserted downstream of exon 3. (J:252536)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:252536 Mar BG, et al., SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. Blood. 2017 Dec 14;130(24):2631-2641
• All: 3 reference(s)