Lrig1^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lrig1^{tm1d(EUCOMM)Wtsi}
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:7614250
• Synonyms: Lrig1^delta
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^{tm1d(EUCOMM)Wtsi} page
• IMPC: Lrig1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332565
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_st2 cassette was inserted at position 94590322 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 94591181. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:332565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 51 strains or lines available

References

• Original: J:332565 Nam HS, et al., Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation. Neural Dev. 2023 Jan 11;18(1):1
• All: 1 reference(s)