Bdnf^em1Bxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bdnf^em1Bxu
• Name: brain derived neurotrophic factor; endonuclease-mediated mutation 1,Baoji Xu
• MGI ID: MGI:7612054
• Synonyms: Bdnf ^NLuc
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^em1Bxu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: Using the CRISPR/Cas9 technique, a NanoLuciferase (NLuc) coding sequence was inserted immediately before the stop codon of the brain derived neurotrophic factor (Bdnf) locus on chromosome 2. (J:345897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:345897 Liao GY, et al., High throughput assay for compounds that boost BDNF expression in neurons. SLAS Discov. 2023 Apr;28(3):88-94
• All: 1 reference(s)