Gfi1^{tm5(GFI1*)Tmo}
Targeted Allele Detail

Summary

• Symbol: Gfi1^{tm5(GFI1*)Tmo}
• Name: growth factor independent 1 transcription repressor; targeted mutation 5, Tarik Moroy
• MGI ID: MGI:7611791
• Synonyms: Gfi1^36Nneo, GFI1-KD
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^{tm5(GFI1*)Tmo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231923
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Most of the coding sequence was replaced with the corresponding human sequence with a single nucleotide polymorphism of asparagine at position 36 (36N). This variant is associated with increased risk for acute myeloid leukemia in humans. A neomycin selection cassette from the targeting vector is retained and leads to an 80-90% reduction of normal GFI1 expression. (J:192927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:231923 Hones JM, et al., GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016 Jun;30(6):1237-45
• All: 4 reference(s)