Itsn2^tm1.1Tmar
Targeted Allele Detail

Summary

• Symbol: Itsn2^tm1.1Tmar
• Name: intersectin 2; targeted mutation 1.1, Tanja Maritzen
• MGI ID: MGI:7610736
• Synonyms: 2KO
• Gene: Itsn2 Location: Chr12:4642792-4763952 bp, + strand Genetic Position: Chr12, 2.09 cM, cytoband A1.1
• Alliance: Itsn2^tm1.1Tmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254735
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N x 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance (Neo) cassette flanked by loxP and FRT sites was placed between exon 2 and 3, and an additional loxP site was introduced 3' to exon 4. A null/knockout allele was created by flp and cre recombinase expression in the germline of mice carrying this allele to remove the neo selection cassette and the loxP-flanked exons 3 and 4. (J:254735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itsn2 Mutation: 89 strains or lines available

References

• Original: J:254735 Gerth F, et al., Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12057-12062
• All: 3 reference(s)