Bnip3l^em1Gord
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bnip3l^em1Gord
• Name: BCL2/adenovirus E1B interacting protein 3-like; endonuclease-mediated mutation 1, Joseph Gordon
• MGI ID: MGI:7608336
• Gene: Bnip3l Location: Chr14:67222688-67246326 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Bnip3l^em1Gord page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Using CRISPR/cas9 endonuclease-mediated homology-directed repair (HDR) genome editing, loxP sites flanking exon 2 of the Bnip3l gene were inserted. (J:101977, J:372206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bnip3l Mutation: 45 strains or lines available

References

• Original: J:372206 Field JT, et al., The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype. Autophagy. 2025 Jul;21(7):1544-1555
• All: 2 reference(s)