Trp53^tm1Sdeb
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Sdeb
• Name: transformation related protein 53; targeted mutation 1, Sumitra Deb
• MGI ID: MGI:7607160
• Synonyms: p53 LSL-L25Q/W26S/R172H
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Sdeb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site flanked STOP cassette was inserted into intron 1 and leucine codon 25 (TTA) in exon 2 was changed to glutamine (CAA), tryptophan codon 26 (TGG) in exon 2 to serine (TCG) and arginine codon 172 (CGC) in exon 5 to histidine (CAC) (p.L25Q, p.W26S, p.R172H). The mutations, in the transactivation domain (TAD) of the encoded peptide, renders the peptide transactivation-deficient. (J:300998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:300998 Vaughan CA, et al., The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3. Nat Commun. 2021 Jan 29;12(1):704
• All: 1 reference(s)