Tg(ITGAL-Ptprc^a*)CSV10Rasch
Transgene Detail

Summary

• Symbol: Tg(ITGAL-Ptprc^a*)CSV10Rasch
• Name: transgene insertion CSV10, William C Raschke
• MGI ID: MGI:7606983
• Synonyms: Tg(ITGAL-Ptprc^a*)CSV10Wcr
• Transgene: Tg(ITGAL-Ptprc^a*)CSV10Rasch Location: unknown
• Alliance: Tg(ITGAL-Ptprc^a*)CSV10Rasch page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ITGAL-Ptprc^a*)CSV10Rasch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptprc (MGI:97810)

• Tg(ITGAL-Ptprc^a*)CSV10Rasch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ITGAL (3683)

  Itgal

  (MGI:96606)

• Mutation details: The human promoter was used to drive leukocyte-specific expression of the minigene. The minigene was altered with a single base change to mutate the catalytic cysteine of the phosphatase domain (C817S), which renders the CD45 protein enzymatically inactive. (J:149759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149759 Panchal RG, et al., Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis. J Biol Chem. 2009 May 8;284(19):12874-85
• All: 3 reference(s)