Rpl11^tm1.1Ypz
Targeted Allele Detail

Summary

• Symbol: Rpl11^tm1.1Ypz
• Name: ribosomal protein L11; targeted mutation 1.1, Yangping Zhang
• MGI ID: MGI:7606815
• Synonyms: Rpl11^flox
• Gene: Rpl11 Location: Chr4:135776665-135780704 bp, - strand Genetic Position: Chr4, 68.34 cM
• Alliance: Rpl11^tm1.1Ypz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was floxed. Recombination removed the selection cassette. (J:332645)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl11 Mutation: 17 strains or lines available

References

• Original: J:332645 Franklin DA, et al., Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. J Biol Chem. 2022 Nov 23;299(1):102739
• All: 1 reference(s)