Tcf7l2^em1Aap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf7l2^em1Aap
• Name: transcription factor 7 like 2, T cell specific, HMG box; endonuclease-mediated mutation 1, Abraham Palmer
• MGI ID: MGI:7596541
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^em1Aap page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc-finger nuclease genome editing technology was used to generate a 10bp deletion in the gene, resulting in a frameshift. (J:253916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 56 strains or lines available

References

• Original: J:253916 Sittig LJ, et al., Genetic Background Limits Generalizability of Genotype-Phenotype Relationships. Neuron. 2016 Sep 21;91(6):1253-1259
• All: 1 reference(s)