Dpp4^{em1(cre/ERT2)Jkpns}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dpp4^{em1(cre/ERT2)Jkpns}
• Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Jonathan Kipnis
• MGI ID: MGI:7595997
• Synonyms: Dpp4-creER^T2
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^{em1(cre/ERT2)Jkpns} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Dpp4^{em1(cre/ERT2)Jkpns} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dpp4 (MGI:94919)

• Mutation details: Using CRISPR/Cas9 technology, a cre/ERT2 fusion gene with a P2A self-cleaving peptide were inserted between the 5' UTR and exon 1 of theDpp4 gene. (J:345366)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dpp4 (mouse) Summary of all recombinase alleles driven by Dpp4. Alliance mouse Dpp4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:345366 Smyth LCD, et al., Identification of direct connections between the dura and the brain. Nature. 2024 Feb 7
• All: 1 reference(s)