Irf6^tm3.1Vmd
Targeted Allele Detail

Summary

• Symbol: Irf6^tm3.1Vmd
• Name: interferon regulatory factor 6; targeted mutation 3.1, Vishva M Dixit
• MGI ID: MGI:7595818
• Synonyms: Irf6^S413E,S424E
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^tm3.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283325
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Serine codons 413 (TCC) and 424 (TCC) in exon 8 were changed to glutamic acid (GAA) (p.S413E, p.S424E) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 7. The neo cassette was removed through subsequent Flp-mediated recombination. The mutations change phosphorylatable residues in the encoded peptide into phosphomimetics. (J:283325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:283325 Oberbeck N, et al., The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature. 2019 Oct;574(7777):249-253
• All: 1 reference(s)