Irf6^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Irf6^tm1.1Vmd
• Name: interferon regulatory factor 6; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:7595815
• Synonyms: Irf6^loxp
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283325
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 3. The neo cassette was removed through subsequent Flp-mediated recombination. (J:283325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:283325 Oberbeck N, et al., The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature. 2019 Oct;574(7777):249-253
• All: 1 reference(s)