Mir27a^tm1.1Bge
Targeted Allele Detail

Summary

• Symbol: Mir27a^tm1.1Bge
• Name: microRNA 27a; targeted mutation 1.1, Baoxue Ge
• MGI ID: MGI:7594053
• Synonyms: MiR-27a^fl
• Gene: Mir27a Location: Chr8:84935301-84935387 bp, + strand Genetic Position: Chr8, 40.58 cM
• Alliance: Mir27a^tm1.1Bge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted on either side of the miR-27a coding region of the gene. A co-inserted A neomycin resistance cassette was removed via Flp-mediated recombination in the germline. (J:345171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir27a Mutation: 2 strains or lines available

References

• Original: J:345171 Teng L, et al., Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3). J Cell Mol Med. 2021 Jan;25(1):73-83
• All: 1 reference(s)