Ano1^tm1.1Mzhu
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1.1Mzhu
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1.1, Min-Sheng Zhu
• MGI ID: MGI:7594039
• Synonyms: Tmem16a^flox
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1.1Mzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236881
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed Neo cassette was inserted of exon 12, and excision of the floxed Neo cassette left behind a single loxP site at the targeted locus. A second single PGK-Neo cassette, flanked by FRT sites and a downstream loxP site, was then introduced downstream of exon 12. (J:236881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 61 strains or lines available

References

• Original: J:236881 Zhang CH, et al., The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun. 2016 Apr 22;7:11358
• All: 7 reference(s)