Shank2^tm1.1Yjh
Targeted Allele Detail

Summary

• Symbol: Shank2^tm1.1Yjh
• Name: SH3 and multiple ankyrin repeat domains 2; targeted mutation 1.1, Yong-hui Jiang
• MGI ID: MGI:7594034
• Synonyms: Shank2^e24flox
• Gene: Shank2 Location: Chr7:143555665-143978231 bp, + strand Genetic Position: Chr7, 88.45 cM
• Alliance: Shank2^tm1.1Yjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281923
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two loxP sites and an frt-flanked neomycin selection cassette were inserted flanking exon 24 of the gene. The neomycin selection cassette was removed in the germline via Flp-mediated recombination. (J:281923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank2 Mutation: 94 strains or lines available

References

• Original: J:281923 Pappas AL, et al., Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. JCI Insight. 2017 Oct 19;2(20)
• All: 2 reference(s)