Trpv4^tm1Gsk
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1Gsk
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, GlaxoSmithKline
• MGI ID: MGI:7593907
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1Gsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268386
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ and neomycin resistance cassette disrupts exons 4 and 5, interrupt the coding sequence at TM1. (J:268386)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 57 strains or lines available

References

• Original: J:268386 Thorneloe KS, et al., N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1 -piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42
• All: 5 reference(s)