Dlk1^tm1.1Stadt
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1.1Stadt
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1.1, Matthias Stadtfeld
• MGI ID: MGI:7593794
• Synonyms: Dlk1^Ven, Dlk1-Venus
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1.1Stadt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237536
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A floxed PGK-neoR cassette and an IRES-Venus reporter construct was inserted into the 3 UTR of the gene. The floxed PGK-neoR cassette was removed via transient transduction with Adeno-Cre in ES cells prior to creating mice. (J:237536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 36 strains or lines available

References

• Original: J:237536 Swanzey E, et al., A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells. Development. 2016 Nov 15;143(22):4161-4166
• All: 3 reference(s)