E2f3^tm1.1Weidu
Targeted Allele Detail

Summary

• Symbol: E2f3^tm1.1Weidu
• Name: E2F transcription factor 3; targeted mutation 1.1, Wei Du
• MGI ID: MGI:7593769
• Synonyms: E2F3^LQ
• Gene: E2f3 Location: Chr13:30090558-30170046 bp, - strand Genetic Position: Chr13, 13.09 cM, cytoband A3.3
• Alliance: E2f3^tm1.1Weidu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Leucine codon 430 (CTG) in exon 7 was changed to glutamine (CAG) (p.L430Q) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 6. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation, in the highly conserved Rb-binding domain of the encoded peptide, blocks retinoblastoma-family-protein-binding. (J:277585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f3 Mutation: 32 strains or lines available

References

• Original: J:277585 Liao Y, et al., Rb-independent E2F3 promotes cell proliferation and alters expression of genes involved in metabolism and inflammation. FEBS Open Bio. 2017 Oct;7(10):1611-1621
• All: 2 reference(s)