Gnptabtm1Ddray
Targeted Allele Detail
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Symbol: |
Gnptabtm1Ddray |
Name: |
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; targeted mutation 1, Dennis Drayna |
MGI ID: |
MGI:7593593 |
Gene: |
Gnptab Location: Chr10:88214996-88283186 bp, + strand Genetic Position: Chr10, 43.86 cM
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Alliance: |
Gnptabtm1Ddray page
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Germline Transmission: |
Earliest citation of germline transmission:
J:260041
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Parent Cell Line: |
BALB/c-I (ES Cell)
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Strain of Origin: |
BALB/cJ
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Allele Type: |
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Targeted (Humanized sequence) |
Mutation: |
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Nucleotide substitutions
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Mutation details: A targeting vector was designed to replace exon 19 with one specifying a change of glutamic acid to lysine at amino acid position 1179 (c.3535G>A (GAA-AAA)) , which is homologous to a human Glu1200Lys mutation correlated with stuttering. The targeting vector also contained an internal ribosome entry site (IRES) to allow initiation of translation of an inserted beta-galactoside gene (beta-gal) for subsequent gene expression studies in tissues, as well as a neomycin resistance cassette (PGK-Neo-pA) for selection of the transfected ES cells.
(J:260041)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gnptab Mutation: |
78 strains or lines available
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Original: |
J:260041 Barnes TD, et al., A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations. Curr Biol. 2016 Apr 13; |
All: |
1 reference(s) |
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