Gsdma3^tm1.1Lty
Targeted Allele Detail

Summary

• Symbol: Gsdma3^tm1.1Lty
• Name: gasdermin A3; targeted mutation 1.1, Liang-Tung Yang
• MGI ID: MGI:7580972
• Synonyms: Gsdma3^fx
• Gene: Gsdma3 Location: Chr11:98517186-98529052 bp, + strand Genetic Position: Chr11, 62.21 cM
• Alliance: Gsdma3^tm1.1Lty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335519
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 7. The neomycin selection cassette was removed via flp-mediated recombination leaving exons 2-7 floxed. (J:335519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdma3 Mutation: 26 strains or lines available

References

• Original: J:335519 Huang LY, et al., Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-like Model. J Invest Dermatol. 2023 Mar 24
• All: 1 reference(s)