Pacsin1^tm1Ciphe
Targeted Allele Detail

Summary

• Symbol: Pacsin1^tm1Ciphe
• Name: protein kinase C and casein kinase substrate in neurons 1; targeted mutation 1, Centre d'ImmunoPhenomique
• MGI ID: MGI:7580971
• Synonyms: Pacsin1^{LoxP-STOP-LoxP-tdTomato}, Pacsin1^LSL-tdT, Pacsin1^{tm1(tdT)Ciphe}
• Gene: Pacsin1 Location: Chr17:27874565-27930092 bp, + strand Genetic Position: Chr17, 14.59 cM, cytoband B1
• Alliance: Pacsin1^tm1Ciphe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337732
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-flanked STOP cassette and tdTomato reporter gene were inserted in the 3 non-coding region of the mouse Pacsin1 gene. Removal of the STOP cassette is necessary for expression of the tdTomato reporter. (J:337732)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pacsin1 Mutation: 31 strains or lines available

References

• Original: J:337732 Valente M, et al., Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells. Nat Immunol. 2023 Apr;24(4):714-728
• All: 1 reference(s)