Pfkfb3^tm1Xen
Targeted Allele Detail

Summary

• Symbol: Pfkfb3^tm1Xen
• Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; targeted mutation 1, Taconic Biosciences
• MGI ID: MGI:7580483
• Gene: Pfkfb3 Location: Chr2:11476241-11558882 bp, - strand Genetic Position: Chr2, 8.73 cM
• Alliance: Pfkfb3^tm1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. (J:290075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pfkfb3 Mutation: 38 strains or lines available

References

• Original: J:290075 Xu Y, et al., Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9
• All: 10 reference(s)