Gt(ROSA)26Sor^{em1(CAG-TBL1XR1/TP63,-EGFP)Mybr}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-TBL1XR1/TP63,-EGFP)Mybr}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Myles Brown
• MGI ID: MGI:7579420
• Synonyms: TgTT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-TBL1XR1/TP63,-EGFP)Mybr} page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/1)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-TBL1XR1/TP63,-EGFP)Mybr} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TBL1XR1 (79718)

  Tbl1xr1

  (MGI:2441730)

  A TBL1XR1/TP63 fusion seen in lymphomas

  human

  TP63 (8626)

  Trp63

  (MGI:1330810)

  A TBL1XR1/TP63 fusion seen in lymphomas

• Gt(ROSA)26Sor^{em1(CAG-TBL1XR1/TP63,-EGFP)Mybr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: CRISPR/Cas9 technology inserted a CAG promoter, a loxP-flanked neomycin/Stop cassette, human TBL1XR1/TP63 fusion cDNA, IRES and EGFP. The TBL1XR1::TP63 rearrangement, in which the breakpoint is in the WD40 repeat domain of TBL1XR1 and right after the transactivation domain of the TP63, is the most common TP63 fusion seen in lymphomas. (J:343472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:343472 Wu G, et al., TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. Sci Transl Med. 2023 Sep 20;15(714):eadi7244
• All: 1 reference(s)