Tg(Pcp2-Rreb1)20Slac
Transgene Detail

Summary

• Symbol: Tg(Pcp2-Rreb1)20Slac
• Name: transgene insertion 20, Susan L Ackerman
• MGI ID: MGI:7579318
• Synonyms: Tg(PCP2-Rreb1/3xV5)20/J
• Transgene: Tg(Pcp2-Rreb1)20Slac Location: unknown
• Alliance: Tg(Pcp2-Rreb1)20Slac page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-Rreb1)20Slac expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rreb1 (MGI:2443664)	V7 cDNA of Rreb1with triple C-terminal V5 tags

• Tg(Pcp2-Rreb1)20Slac expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pcp2 (MGI:97508)

• Mutation details: The V7 cDNA of Rreb1with triple C-terminal V5 tags was inserted into the BamH1 site of the fourth exon of the L7/Pcp2 minigene, such that the mouse Pcp2 promoter drives expression of the V7 transcript, and this randomly inserted into the genome after injection into the pronucleus of a C57BL/6J zygote. (J:344394)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:344394 Cazzaro S, et al., Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2217128120
• All: 1 reference(s)