Tmc1^em5Ftpl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmc1^em5Ftpl
• Name: transmembrane channel-like gene family 1; endonuclease-mediated mutation 5, Robert Fettiplace
• MGI ID: MGI:7579138
• Synonyms: Tmc1 p.E520Q
• Gene: Tmc1 Location: Chr19:20760822-20931566 bp, - strand Genetic Position: Chr19, 13.98 cM, cytoband B
• Alliance: Tmc1^em5Ftpl page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 genome editing is used to introduce an E520Q mutation to modify residues near the putative channel pore. (J:344636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmc1 Mutation: 63 strains or lines available

References

• Original: J:344636 Fettiplace R, et al., The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2210849119
• All: 1 reference(s)