Ptpn22^tm1.1Rhd
Targeted Allele Detail

Summary

• Symbol: Ptpn22^tm1.1Rhd
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1.1, Rikard Holmdahl
• MGI ID: MGI:7579055
• Synonyms: PTPN22^C129S, Ptpn22^tm1.1Hlmdl
• Gene: Ptpn22 Location: Chr3:103767111-103819563 bp, + strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Ptpn22^tm1.1Rhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342728
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cysteine codon 129 (TGT) in exon 5 was changed to serine (TCC) (p.C129S) and a loxP site, tACE-Cre (Cre gene driven by the testis-specific angiotensin I converting enzyme gene promoter), a neomycin resistance gene cassette and a second loxP site were inserted into intron 5. The neo cassette was self-excised through testis-expressed Cre-mediated recombination. The mutation leads to reduced catalytic activity of the encoded peptide. (J:342728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn22 Mutation: 50 strains or lines available

References

• Original: J:342728 James J, et al., Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation. Elife. 2022 May 19;11:e74549
• All: 1 reference(s)