Tgfbr1^em1Yixi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tgfbr1^em1Yixi
• Name: transforming growth factor, beta receptor I; endonuclease-mediated mutation 1, Yichuan Xiao
• MGI ID: MGI:7576933
• Synonyms: Tgfbr1^K268R
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^em1Yixi page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Lysine codon 268 (AAA) in exon 4 was changed to arginine (AGA) (p.K268R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks ubiquitination of the residue in the encoded peptide. (J:343892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 32 strains or lines available

References

• Original: J:343892 Pei S, et al., BFAR coordinates TGFbeta signaling to modulate Th9-mediated cancer immunotherapy. J Exp Med. 2021 Jul 5;218(7)
• All: 1 reference(s)