Fgfr3^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Fgfr3^tm1.1Ics
• Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7575938
• Synonyms: Fgfr3^A385E
• Gene: Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
• Alliance: Fgfr3^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/cN

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A 1553 GCA>GAA substitution in exon 9 (A385E) and a floxed neo and Prm1-cre cassette were inserted via homologous recombination. Following male germline transmission the floxed cassette was removed. (J:344353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr3 Mutation: 52 strains or lines available

References

• Original: J:344353 Cornille M, et al., FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model. J Exp Med. 2022 Apr 4;219(4):e20201879
• All: 1 reference(s)