Sv2a^tm1.4Ygua
Targeted Allele Detail

Summary

• Symbol: Sv2a^tm1.4Ygua
• Name: synaptic vesicle glycoprotein 2a; targeted mutation 1.4, Yihui Guan
• MGI ID: MGI:7574709
• Gene: Sv2a Location: Chr3:96088543-96102499 bp, + strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Sv2a^tm1.4Ygua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a neomycin resistance gene flanked by self-deletion anchor sites, a lox2272 site, a SA-2A-dTomato-polyA cassette in reverse orientation, a second loxP and lox2272 sites were inserted downstream of exon 3 in intron 3. The neomycin resistance gene was self-excised. Cre-mediated recombination either inverted the dTomato cassette and exon 3 using the loxP sites, such that the dTomato cassette is now upstream of exon 3 or inverted just the dTomato cassette using lox2272. Cre-mediated excionsion using loxP deleted exon 3. (J:329964)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sv2a Mutation: 36 strains or lines available

References

• Original: J:329964 Kong Y, et al., The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment. Front Cell Dev Biol. 2021;9:609908
• All: 1 reference(s)