Axl^em1Jkrh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Axl^em1Jkrh
• Name: AXL receptor tyrosine kinase; endonuclease-mediated mutation 1, Jin Kyung Rho
• MGI ID: MGI:7574698
• Gene: Axl Location: Chr7:25456698-25488130 bp, - strand Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
• Alliance: Axl^em1Jkrh page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNA 5-GAGGATGGGCAGGGTCCCGC-3 generated a 17-bp deletion (consisting of two deletions shown in uppercase with intervening wild-type sequence in lowercase; AGGGTCCCGCtggccTGGTGGT) in exon 1. (J:344269)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axl Mutation: 58 strains or lines available

References

• Original: J:344269 Im K, et al., AXL receptor tyrosine kinase inhibition improves the anti-tumor effects of CD8(+) T cells by inducing CD103(+) dendritic cell-mediated T cell priming. Biochem Biophys Res Commun. 2023 Nov 5;680:7-14
• All: 1 reference(s)