Tg(GP1BA)1Zmr
Transgene Detail

Summary

• Symbol: Tg(GP1BA)1Zmr
• Name: transgene insertion 1, Zaverio M Ruggeri
• MGI ID: MGI:7574562
• Synonyms: hGPIbalpha^Tg
• Transgene: Tg(GP1BA)1Zmr Location: unknown
• Alliance: Tg(GP1BA)1Zmr page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GP1BA)1Zmr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GP1BA (2811)

  Gp1ba

  (MGI:1333744)

• Mutation details: A 6kb genomic EcoRI restriction fragment, containing the entire human glycoprotein Ib platelet subunit alpha gene, was inserted. Only one line, containing fewer than five copies of the transgene, stably expressed the transgene on platelet surfaces. (J:339858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:339858 Ware J, et al., Expression of human platelet glycoprotein Ib alpha in transgenic mice. J Biol Chem. 1993 Apr 15;268(11):8376-82
• All: 4 reference(s)