Rtel1^em1Khk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rtel1^em1Khk
• Name: regulator of telomere elongation helicase 1; endonuclease-mediated mutation 1, Klaus H Kaestner
• MGI ID: MGI:7574406
• Synonyms: Rtel1^M492K, Rtel1^M492Kkhk
• Gene: Rtel1 Location: Chr2:180961532-180998409 bp, + strand Genetic Position: Chr2, 103.63 cM
• Alliance: Rtel1^em1Khk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting generated a point mutation in codon 492 of Rtel1, changing methionine to lysine (M492K). (J:344243)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtel1 Mutation: 74 strains or lines available

References

• Original: J:344243 Smoom R, et al., Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1. Nat Commun. 2023 Oct 23;14(1):6708
• All: 1 reference(s)