Egfr^tm1.1Grj
Targeted Allele Detail

Summary

• Symbol: Egfr^tm1.1Grj
• Name: epidermal growth factor receptor; targeted mutation 1.1, Gibbes R Johnson
• MGI ID: MGI:7574230
• Synonyms: KI EGFR
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^tm1.1Grj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343982
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Lysine codon 747 (AAG) in exon 19 was changed to methionine (ATG) (p.K747M) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 18. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation renders the encoded peptide kinase-dead. (J:343982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 85 strains or lines available

References

• Original: J:343982 Tripurani SK, et al., Suppression of Wnt/beta-catenin signaling by EGF receptor is required for hair follicle development. Mol Biol Cell. 2018 Nov 1;29(22):2784-2799
• All: 1 reference(s)