Adrb2^tm1.1Stam
Targeted Allele Detail

Summary

• Symbol: Adrb2^tm1.1Stam
• Name: adrenergic receptor, beta 2; targeted mutation 1.1, Jonathan S Stamler
• MGI ID: MGI:7572493
• Synonyms: ADRB2^C265S
• Gene: Adrb2 Location: Chr18:62310887-62313030 bp, - strand Genetic Position: Chr18, 35.1 cM
• Alliance: Adrb2^tm1.1Stam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Cysteine codon 265 (TGC) was changed to serine (TCC) (p.C265S) and an FRT and loxP site flanked neomycin resistance gene cassette was inserted downstream of the gene. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation blocks S-nitrosylation of the residue in the encoded peptide. (J:342739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adrb2 Mutation: 33 strains or lines available

References

• Original: J:342739 Fonseca FV, et al., S-nitrosylation is required for beta2AR desensitization and experimental asthma. Mol Cell. 2022 Aug 18;82(16):3089-3102.e7
• All: 1 reference(s)