Otofem3Bros
Endonuclease-mediated Allele Detail
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Symbol: |
Otofem3Bros |
Name: |
otoferlin; endonuclease-mediated mutation 3, Nils Brose |
MGI ID: |
MGI:7571453 |
Synonyms: |
OtofD1841/1842A, OtofMDDA |
Gene: |
Otof Location: Chr5:30524406-30619276 bp, - strand Genetic Position: Chr5, 16.48 cM, cytoband B1
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Alliance: |
Otofem3Bros page
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Allele Type: |
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Endonuclease-mediated (Not Specified) |
Mutation: |
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Nucleotide substitutions
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Mutation details: This mouse line was generated by site-directed CRISPR-Cas9 mutagenesis in C57BL/6NCrl mice causing a D1821A/D1822A mutation (Corresponds to D1841A/D1842A mutation in the isoform e peptide coded for by the human ortholog). Additional silent mutations were introduced. The mutated exon38 now reads:(5')gtggctgaagggccagcaggaggacaaacaggacacagatgtccactatcactccctcacgggggagggcaacttcaactggagatacctcttccccttcgactacctagcggccgaagagaagatcgttatgtccaaaaaggagtctatgttctcctgggatgagacggagtacaagatccctgcgcggctcaccctgcagatctgggacgctgaTcacttctcggctgCTgCcttcctgg (3')
(J:344236)
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Inheritance: |
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Not Specified |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Otof Mutation: |
108 strains or lines available
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Original: |
J:344236 Chen H, et al., Probing the role of the C(2)F domain of otoferlin. Front Mol Neurosci. 2023;16:1299509 |
All: |
1 reference(s) |
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