Setdb1^tm1.2Yshk
Targeted Allele Detail

Summary

• Symbol: Setdb1^tm1.2Yshk
• Name: SET domain, bifurcated 1; targeted mutation 1.2, Yoichi Shinkai
• MGI ID: MGI:7571449
• Gene: Setdb1 Location: Chr3:95230836-95264513 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Setdb1^tm1.2Yshk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 15 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 16 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre-mediated recombination removed the floxed exons. (J:227243)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setdb1 Mutation: 58 strains or lines available

References

• Original: J:227243 Liu S, et al., Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells. Genes Dev. 2014 Sep 15;28(18):2041-55
• All: 1 reference(s)