Hprt1^{tm6(CAG-Dll1/Dll4,-DsRed)Gos}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm6(CAG-Dll1/Dll4,-DsRed)Gos}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 6, Achim Gossler
• MGI ID: MGI:7571319
• Synonyms: Hprt^{Dll1ECD_Dll4ICD}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm6(CAG-Dll1/Dll4,-DsRed)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274018
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus an inverted CAG promoter driving expression of s fusion protein containing the extracellular domains of Dll1 and the intracellular domain of Dll4 followed by an IRES and DsRed reporter gene. Cre-mediated recombination is required to achieve expression. (J:274018)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:274018 Tveriakhina L, et al., The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife. 2018 Oct 5;7:e40045
• All: 1 reference(s)