Gt(ROSA)26Sor^{tm3(CMV-TYMP)Tai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CMV-TYMP)Tai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, TAIHO Pharmaceutical
• MGI ID: MGI:7571181
• Synonyms: R26-hTP-KI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CMV-TYMP)Tai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339776
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(CMV-TYMP)Tai} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TYMP (1890)

  Tymp	(MGI:1920212)

• Mutation details: The targeting vector consisting of the CMV promoter, human TYMP cDNA, and a loxP-flanked PGK-neomycin selection cassette inserted into the locus. (J:339776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:339776 Harada N, et al., Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase. J Biol Chem. 2023 Feb 10;299(3):103002
• All: 1 reference(s)