Upp1^tm1(TYMP)Tai
Targeted Allele Detail

Summary

• Symbol: Upp1^tm1(TYMP)Tai
• Name: uridine phosphorylase 1; targeted mutation 1, TAIHO Pharmaceutical
• MGI ID: MGI:7571180
• Synonyms: Upp1-hTP-KI
• Gene: Upp1 Location: Chr11:9068103-9086170 bp, + strand Genetic Position: Chr11, 6.13 cM, cytoband A1-2
• Alliance: Upp1^tm1(TYMP)Tai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339776
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Upp1^tm1(TYMP)Tai expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TYMP (1890)

  Tymp	(MGI:1920212)

• Mutation details: The human TYMP cDNA and a PGK-neomycin-pA replaced the first two coding exons. Expression of the human mRNA was detected in various tissues such as thymus, heart, lung, spleen, kidney, stomach, intestine, and brain. (J:339776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Upp1 Mutation: 66 strains or lines available

References

• Original: J:339776 Harada N, et al., Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase. J Biol Chem. 2023 Feb 10;299(3):103002
• All: 1 reference(s)