Bax^tm1.1Fuch
Targeted Allele Detail

Summary

• Symbol: Bax^tm1.1Fuch
• Name: BCL2-associated X protein; targeted mutation 1.1, Yaron Fuchs
• MGI ID: MGI:7570089
• Synonyms: Bax^fl
• Gene: Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
• Alliance: Bax^tm1.1Fuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343605
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6 surrounding the catalytic region QACGG was flanked by loxP sites. A FRT-flanked neomycin cassette was inserted between the loxP sites and was removed via flp-mediated recombination. (J:343605)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bax Mutation: 24 strains or lines available

References

• Original: J:343605 Yusupova M, et al., Apoptotic dysregulation mediates stem cell competition and tissue regeneration. Nat Commun. 2023 Nov 20;14(1):7547
• All: 1 reference(s)